Stroke
Conditions
Interventions
Precision Positioning Group:Repetitive transcranial magnetic stimulation (rTMS) will be administered based on individualized brain network characteristics to determine the stimulation target. The trea
Regular Positioning Group:Stimulation will be applied to the conventional primary motor cortex (M1) once daily, five times per week, for a total of three consecutive weeks
Sponsors
Yongzhou Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meets the "Stroke" diagnostic criteria established by the 4th National Academic Conference on Cerebrovascular Diseases; 2. Diagnosed with unilateral ischemic/hemorrhagic stroke confirmed by CT/MRI; 3. Aged 18–80 years, any gender; 4. Conscious, with stable vital signs and the ability to maintain static sitting balance; 5. Disease duration <=12 months, all first-time incidents; 6. Presence of clear post-stroke upper limb dysfunction (PSUD), with upper limb stages of Brunnstrom II–V; 7. First onset of stroke; 8. Able to cooperate with assessments and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Concurrent participation in other clinical trials or inability to complete the full course of treatment; 2. Presence of secondary dysfunction due to epilepsy, severe cardiovascular disease, or endocrine disorders; 3. Upper limb amputation or other conditions affecting upper limb function; 4. Contraindications to MRI scanning (e.g., patients with cardiac pacemakers, intracranial aneurysm clips post-surgery, or ferromagnetic implants); 5. Contraindications to rTMS therapy (e.g., intracranial metal implants, cardiac pacemakers, cochlear implants, or elevated intracranial pressure); 6. Previous history of electroconvulsive therapy or rTMS treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment for the Upper Extremity(FMA-UE);Motor Evoked Potential (MEP);centralmotor condition time(CMCT);fractional anisotropy(FA);centralmotor condition time(CMCT);Corticospinal Tract - Fractional Anisotropy Asymmetry Index(CST-FAAI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Action Research Arm Test(ARAT);modified Barthel Index(MBI); | — |
Countries
China
Contacts
Public ContactXiong Mingyue
Yongzhou Central Hospital
Outcome results
None listed