Cirrhosis
Conditions
Interventions
Healthy control group:None
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 75 Years
Inclusion criteria
Inclusion criteria: Subject Inclusion Criteria:All selected candidates were diagnosed based on the Guidelines for the Diagnosis and Treatment of Liver Cirrhosis and the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2019 Edition) published by the Hepatology Branch of the Chinese Medical Association. The diagnosis of cirrhosis requires a comprehensive consideration of etiology, medical history, clinical manifestations, complications, treatment process, testing, imaging and histology. All enrolled patients met the diagnostic criteria for liver cirrhosis by clinical, imaging (ultrasound, CT, MRI), or liver biopsy (e.g., Metavir score F4, Ishak score 5-6). Inclusion criteria for the healthy control group: 1. Age between 16 and 75 years old; 2. No cirrhosis and liver fibrosis related pathological states; 3. No serious chronic diseases, such as cardiovascular disease, liver and kidney failure, malignant tumors, etc.; 4. The results of physical examination and basic laboratory tests (liver function, coagulation function, etc.) are within the normal range; 5. No family history of liver cirrhosis and liver fibrosis; 6. No history of hepatitis virus, schistosomiasis and other related exposures.
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for subjects: (1) Those with missing clinical data were excluded; (2) Exclude patients with cardiovascular disease, diabetes, primary kidney disease, hematological disease, malignant tumor, etc.; (3) Previous liver transplantation; (4) Patients infected with human immunodeficiency virus and new coronavirus; (5) Patients who have used blood products in the past 1 month; (6) Patients with elevated procalcitonin and obvious acute bacterial infection and sepsis; (7) Patients with rheumatic immune system diseases; (8) Patients who died from non-liver disease causes. 2.Exclusion Criteria: (1) Suffering from acute and chronic hepatitis, liver fibrosis and cirrhosis-related diseases;(2) There are comorbidities that may interfere with the results, such as autoimmune diseases, active infection, etc; (3) Recent (within 3 months) use of drugs that may affect the research results, such as immunosuppressants, hormones, etc; (4) Participate in other clinical trials or receive special treatment, such as surgery, radiotherapy, etc; (5) Pregnant or lactating women; (6) Long-term alcoholism, drug abuse, etc.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Levels of inflammatory markers; | — |
Countries
China
Contacts
Public ContactHong Rutao
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed