Stroke
Conditions
Interventions
Experimental Group:Personalized rTMS intervention
Control Group:Conventional rehabilitation therapy + Traditional rTMS
Sponsors
Second Xiangya Hospital of CSU
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with clinically and radiologically confirmed first-time unilateral stroke; 2. Aged 30-75 years, with clear upper limb motor dysfunction; 3. Able to cooperate in completing magnetic resonance imaging (MRI), electroencephalography (EEG), and rTMS treatment; 4. Have not received other brain stimulation therapies and have no severe cognitive or mental disorders; 5. No cognitive impairment, with a Mini-Mental State Examination (MMSE) score >=24; 6. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of cardiac pacemakers or other metal implants causing intolerance; 2. Severe cardiovascular, hepatic, renal dysfunction, or other systemic diseases; 3. History of neurological disorders such as Parkinson's disease or multiple sclerosis; 4. Severe mental illness affecting compliance; 5. Intolerance to magnetic stimulation; 6. Female subjects who are pregnant, breastfeeding, or test positive for pregnancy during screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FMA-UE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes before and after treatment in T1, T2, Diffusion-Weighted Imaging (DWI), Diffusion Tensor Imaging (DTI), resting-state and task-based functional MRI (rs-fMRI);Serological biomarkers before and after treatment (TNF-a, IL-6, C-reactive protein, Complement C3, D-dimer, NSE);Changes in EEG cortical excitability and neural network synchronization;Barthel Index; | — |
Countries
China
Contacts
Public ContactYing Kong
Second Xiangya Hospital of CSU
Outcome results
None listed