Chronic thromboembolic pulmonary hypertension
Conditions
Interventions
Index test:AI diagnostic model construction using pulmonary ventilation/perfusion imaging and FAPI PET/CT imaging
Sponsors
Beijing Chaoyang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. V/Q SPECT imaging and right heart catheterization were completed and the clinical diagnosis was CTEPH or excluded from the diagnosis of CTEPH. After 3 months of standardized anticoagulant therapy, imaging confirmed the presence of chronic thrombosis. b. Mean pulmonary artery pressure (mPAP>=25mmHg) and pulmonary artery wedge pressure (PAWP=25mmHg) and pulmonary artery wedge pressure (PAWP=25mmHg) and pulmonary capillary pressure (PCWP < 15mmHg) at rest; b. All diseases known to cause increased pulmonary arterial pressure were excluded. 2. No history of myocardial infarction and severe coronary atherosclerotic disease. 3. No serious comorbidities or clinical instability. 4. CTEPH patients signed informed consent and agreed to be followed up for 2 years after enrollment.
Exclusion criteria
Exclusion criteria: 1. Age < 18 years old; 2. Poor image quality, which cannot meet the diagnostic requirements of artificial intelligence; 3. No definite clinical diagnosis was obtained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sensitivity, specificity and AUC of the AI model;The SSIM and PSNR of the predicted images generated by the AI image generation model and the actual imaging results after treatment were compared;Pre-treatment and post-treatment perfusion difference maps generated;Al18F-NOTA-FAPI-04 imaging; | — |
Countries
China
Contacts
Public ContactLi Wang
Beijing Chaoyang Hospital, Capital Medical University
Outcome results
None listed