Painless Gastrointestinal Endoscopy
Conditions
Interventions
Trails I: Group L (65-70):Sufentanil 5µg + Remimazolam Besylate 0.15 mg/kg (1 mg/mL)
Trails I: Group H (>70):Sufentanil 5µg + Remimazolam Besylate 0.1 mg/kg (1 mg/mL)
Trial II: Group R:Sufentanil 0.05µg/kg + Remimazolam Besylate 0.15mg/kg
Trial II: Group P:Sufentanil 0.05µg/kg + Propofol 1mg/kg
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 65-75 years, regardless of gender; 2.BMI 18.5-30 kg/m^2; 3.ASA physical status Class I-II; 4.STOP-Bang score <5; 5.Patients deemed suitable for painless gastroscopy, colonoscopy, or combined gastrointestinal endoscopy after anesthesia assessment clinic evaluation; 6.Voluntarily participated and provided signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.Chronic pain patients on long-term analgesics, psychoactive medications (including opioids, NSAIDs, sedatives, antidepressants), or alcohol abusers. 2.Preoperative clinically significant elevation of liver/kidney function markers (ALT, AST, BUN, Cr); 3.Pre-existing severe central nervous system disorders or major psychiatric conditions; 4.Individuals with opioid addiction or dependence; 5. Participation in other clinical trials within 4 weeks prior; 6.Body weight is 15% below or above the standard weight
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Median Effective Dose of Remimazolam Besylate for Successful Gastroscope Insertion in Elderly Patients of Different Age Groups;Incidence of Low oxygen (Trial II); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Hypoxemia;Vital Signs;Anesthesia Recovery Time Metrics;Anesthesia-Related Medications;Adverse Reactions;Success rate of initial mirror placement;Incidence of body movement events;Subclinical respiratory depression incidence rate;vital signs;Anesthesia recovery time; | — |
Countries
China
Contacts
Public ContactLixin An
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed