Nausea and vomiting after laparoscopic surgery
Conditions
Interventions
Sufentanil Group:Sufentanil PCIA
Tegilizumab Group:Tegileridine PCIA
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Planned elective laparoscopic surgery under general anesthesia, not performed during the daytime; 2. Age 18-70 years; 3. ASA physical status classification I-III; 4. BMI between 18 kg/m^2 and 30 kg/m^2; 5. Patients at moderate to high risk for PONV (Apfel score >= 2); 6. Postoperative analgesia using patient-controlled intravenous analgesia (PCIA); 7. Fully understand the purpose and significance of this study, voluntarily sign the informed consent form, and willingly comply with the study procedures.
Exclusion criteria
Exclusion criteria: 1.Patients who are allergic to any component of opioid drugs or investigational drugs; 2.Severe liver and kidney dysfunction: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) >= 3 times the upper limit value, total bilirubin (TBIL) >= 3 times the upper limit value, and serum creatinine >= 1.5 times the upper limit value; 3.Those with impaired cognitive function, poor communication, or those who need continuous sedation after surgery and are unable to be evaluated; 4.The researchers believed that the subjects were not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of PONV within 72 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of PONV;Postoperative pain score;The frequency and incidence of postoperative nausea and vomiting respectively;The use of remedial antiemetic drugs;First exhaust time;The first time to get out of bed and move around;Adverse events;Postoperative PCIA compression statistics; | — |
Countries
China
Contacts
Public ContactGuo Chen
West China Hospital of Sichuan University
Outcome results
None listed