Late life depression
Conditions
Interventions
Elderly patients with depression:None
Control group :None
Sponsors
Beijing Anding Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Elderly patients with depression: 1. All participants meet the diagnostic criteria for major depressive disorder according to DSM-IV; 2. First episode of depression occurring after age 60; 3. Age >= 60 years, right-handed, with at least a junior high school education; 4. Written informed consent has been obtained; 5. Total score on the 17-item Hamilton Depression Rating Scale (HAMD-17) >= 17. Control Group: 1. Age >= 60 years, right-handed, with education level of junior high school or higher; 2. No significant somatic illnesses or psychiatric disorders meeting diagnostic criteria; 3. No personal or family history of psychiatric disorders; 4. Written informed consent has been obtained.
Exclusion criteria
Exclusion criteria: 1. Presence of conditions that interfere with neuropsychological assessment, such as severe hearing or visual impairment, aphasia, or dominant-side hemiplegia; 2. No use of medications that may affect cognitive function; 3. No concurrent severe failure of vital organs, including heart, liver, or kidney; 4. No history of prior cerebrovascular events; 5. No cognitive impairment due to large infarcts in critical isolated regions, or neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia, or Huntington’s disease; 6. No cognitive impairment due to other causes, including traumatic brain injury, tumors, infections, metabolic disorders, normal pressure hydrocephalus, folate or vitamin B12 deficiency, or hypothyroidism; 7. Exclusion of other white matter diseases; 8. No history of epilepsy, use of special medications, or alcohol/drug dependence; 9. No contraindications to MRI, including cardiac pacemakers, neural stimulators, artificial metallic heart valves, intracorporeal ferromagnetic foreign bodies, severe claustrophobia, or marked hyperthermia; 10. No electroconvulsive therapy (ECT) within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional anisotropy;Mean diffusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting Plasma Glucose;Cholesterol;High-density Lipoprotein;Triglycerides;Homocysteine; | — |
Countries
China
Contacts
Public ContactZhang Xinqiao
Beijing Anding Hospital Affiliated to Capital Medical University
Outcome results
None listed