Advanced Age-Related Diminished Ovarian Reserve
Conditions
Interventions
Control Group:Conventional treatment protocols for assisted reproductive technology.
Observation Group 1:On the basis of the conventional treatment regimen, starting from the first day of entering the assisted reproductive technology (ART) cycle and continuing until the trigger day, t
Observation Group 2:On the basis of the conventional treatment regimen, injectable Coenzyme I was administered 60 days in advance. The administration was via intramuscular injection, with a dosage of
Sponsors
Qinzhou Maternity and Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>35 years; 2. Comply with IVF/ICSI indications; 3. Body mass index (BMI)>=18 kg/m^2 and <=38 kg/m^2; 4.AMH < 1.2 ng/ml; 5. Sinus follicle count (AFC) < 7; 6. 10 mIU/ml < FSH < 25 mIU/ml; 7. Agree to participate in this study and be willing to complete follow-up visits.
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. Premature ovarian failure due to genetic causes: such as Turner syndrome or chromosomal abnormalities;Underlying diseases: blood diseases, significant thrombocytopenia, diabetes, hypertension, thyroid diseases, thrombotic diseases, tumor diseases, autoimmune diseases; 3. Uterine malformations or lesions (such as submucosal fibroids, endometrial hyperplasia, endometrial effusion or endometrial adhesions, thin endometrium); 4. Male oligoasthenospermia or azoospermia; 5. Those who are allergic to Coenzyme I and its derivatives; 6. Those who have other contraindications to assisted reproductive technology.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of oocytes retrieved;Number of MII oocytes;Number of GV oocytes;Number of other abnormal oocytes;Number of viable embryos;Number of transferable embryos;Number of embryos cultured to blastoc;Number of high-quality blastocysts;Number of blastocysts formed;Number of cryopreserved blastocysts;Biochemical pregnancy rate;Ectopic pregnancy rate;Combined intrauterine and extrauterine pregnancy rate;Early miscarriage rate; | — |
Countries
China
Contacts
Public ContactHongbo Wu
Qinzhou Maternity and Child Healthcare Hospital
Outcome results
None listed