ERCP
Conditions
Interventions
Oliceridine group:All patients were placed in a semi-prone position (right side elevated by 30 degrees). Patients in the oliceridine group received intravenous administration of 0.4 mg/kg esketamine,
Control group:The control group received intravenous 0.4 mg/kg esketamine, 2 ml saline, and 0.2–0.4 mg/kg remifentanil, and all patients were maintained on 1–1.25 mg/kg/h remifentanil by infusion.
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients scheduled for endoscopic retrograde cholangiopancreatography (ERCP), aged >=65 years, with an American Society of Anesthesiologists (ASA) physical status classification of III–IV.
Exclusion criteria
Exclusion criteria: 1. Patients with history of mental illness, using antipsychotic drugs 2. Patients with allergies or contraindications to Cyclopropane, Esketamine, Oliceridine, and soybeans 3. Patients with severe risk of elevated blood pressure or intracranial pressure; poorly controlled or untreated hypertensive patients 4. Patients with severe hepatic and renal functional decompensation 5. Abnormal electrocardiogram: including corrected QT interval greater than 450 milliseconds.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypoxia-related adverse events occurring during sedation; | — |
Countries
China
Contacts
Public ContactLu Xinge
Tongji University School of Medicine,Shanghai East Hospital
Outcome results
None listed