Extensive burn injuries
Conditions
Interventions
Bupivacaine liposome group:Bupivacaine liposome injection 266mg can be used directly
Bupivacaine group:Bupivacaine injection (0.5%, 10ml, containing 50mg of bupivacaine) was diluted with 0.9% normal saline to 20ml, with a final concentration of 0.25%
Sponsors
Chinese People's Liberation Army Northern Theater Command General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years; 2. Second- or third-degree burns on the lower limb thighs requiring surgical debridement; 3. Burn area 10%-30%; 4. ASA classification II-III; 5. Planned surgical treatment under general anesthesia; 6. Able to understand and cooperate with pain assessment; 7. Signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of allergy to amide local anesthetics (such as lidocaine, bupivacaine, etc.); 2. Allergy to eggs, soy, or lipid emulsions (liposomal bupivacaine contains phospholipid components); 3. Pregnant or breastfeeding women; 4. Severe mental illness, dementia, or cognitive impairment preventing cooperation with assessment; 5. Severe cardiovascular disease (NYHA class III-IV heart function, severe arrhythmia, recent myocardial infarction); 6. Severe liver dysfunction (Child-Pugh class C) or renal dysfunction (serum creatinine >200 µmol/L); 7. Coagulation disorders (PT > 1.5 times normal value or PLT < 80 × 10^9/L); 8. Infectious shock, sepsis, or multi-organ failure; 9. History of long-term opioid use (continuous use for more than 1 month); 10. Skin infection or anatomical abnormalities at the site of nerve block puncture.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score 48 hours after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The sufentanil consumption within 0-24 hours and 24-48 hours after the operation was converted to morphine milligram equivalents for comparison; | — |
Countries
China
Contacts
Public ContactShilei Zhao
The General Hospital of the PLA Northern Theater Command
Outcome results
None listed