Colorectal neoplasm surgery
Conditions
Interventions
Trial group:Induction of anesthesia with remimazolam at 0.30 mg/kg and continuous infusion of remimazolam at 0.2-1.0mg/kg/h for maintenance of anesthesia.
Control group:Anesthesia induction with 2 mg/kg of propofol and continuous infusion of 3-10mg/kg/h of propofol for anesthesia maintenance.
Sponsors
Yibin Second People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with colorectal cancer via colonoscopy and pathological examination, and scheduled for elective laparoscopic radical resection of colorectal cancer; 2. Age >= 65 years; 3. Body Mass Index (BMI) between 18.5 kg/m^2 and 24 kg/m^2 (inclusive); 4. No known history of delirium prior to surgery; 5. American Society of Anesthesiologists (ASA) physical status classification: I-III; 6. Mini-Mental State Examination (MMSE) score >= 25; 7. Patients have provided informed consent for participation in the study.
Exclusion criteria
Exclusion criteria: 1. Those with severe functional disorders of important organs such as the heart, brain, lungs, liver and kidneys; 2. Those with a history of neurological or mental disorders, long-term use of sedative-hypnotic or antipsychotic drugs, or long-term stress stimulation or psychological disorders; 3. History of alcohol abuse and dependence on painkillers; 4. Those who are allergic to the drugs used in the research; 5. Those with a history of abnormal anesthesia or surgical recovery in the past; 6. Emergency surgery; 7. Patients who cannot cooperate; 8. Recently or currently participating in other clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity, duration, and subtyping of postoperative delirium;Mean arterial pressure;Heart Rate;Inflammatory markers (including interleukin-6 levels, interleukin-1ß, and neutrophil-to-lymphocyte ratio);Recovery time of spontaneous breathing;The recovery time of orientation;Extubation time; | — |
Countries
China
Contacts
Public ContactXu Jian
Yibin Second People's Hospital
Outcome results
None listed