Neonatal sepsis
Conditions
Interventions
Index test:Multimodal Predictive Model
Sponsors
Affiliated Hospital of Jining Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for neonatal sepsis specified in the Expert Consensus on Diagnosis and Treatment of Neonatal Sepsis (2024), including clinical diagnosis and definitive diagnosis. (1) Clinical diagnosis: Presence of abnormal clinical manifestations, plus meeting any one of the following conditions: >= 2 positive results in non-specific blood tests; Cerebrospinal fluid test showing changes consistent with purulent meningitis; Detection of pathogenic bacterial DNA in blood or cerebrospinal fluid. (2) Definitive diagnosis: Presence of abnormal clinical manifestations, plus positive results in blood culture or cerebrospinal fluid (or other sterile cavity fluid) culture.
Exclusion criteria
Exclusion criteria: 1. Presence of severe congenital malformations at birth; 2.Cases with contraindications to lumbar puncture (platelet count < 20,000/µL, clinical bleeding with known bleeding tendency, infection or anatomical defect at the lumbar puncture site, and cardiovascular instability); 3.Failed lumbar puncture or bloody cerebrospinal fluid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Purulent meningitis; | — |
Countries
China
Contacts
Public ContactHuabin Wang
Affiliated Hospital of Jining Medical University
Outcome results
None listed