Bipolar disorder
Conditions
Interventions
BD experimental group:Transcranial temporal interference stimulation
BD control group:Sham TI
Sponsors
The Second Affiliated Hospital of Xinxiang Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for study participants: 1. Diagnostic criteria for bipolar disorder according to DSM-5; 2. Aged between 18 and 60 years old, male or female; 3. Emotional symptoms in acute phase (depressive or manic phase); 4. Voluntary participation in the study and signing of informed consent form; 5. Ability to comply with the protocol; 6. Passing the tTIS adult safety screening questionnaire.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1. Concurrent brain organic lesions, intellectual disability, or other physical illnesses; 2. Intracranial hypertension; 3. Frequent and persistent migraines; 4. History of epilepsy or family history of epilepsy; 5. Presence of metallic implants in the body; 6. Severe drug or alcohol dependence; 7. Pregnant or breastfeeding women; 8. Currently undergoing MECT treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rs-EEG (resting-state Electroencephalogram);Functional magnetic resonance imaging, fMRI;Young Mania Rating Scale, YMRS;Hamilton depression scale, HAMD;Hamilton anxiety scale, HAMA;Pittsburgh Sleep Quality Index, PSQI;Brief psychiatric inventory, BPRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Event-related potential analysis, ERP (Event Related Potentials) ; | — |
Countries
China
Contacts
Public ContactJuan Wang
The Second Affiliated Hospital of Xinxiang Medical College;
Outcome results
None listed