Non-small Cell Lung Cancer
Conditions
Interventions
Experimental Group (Single-arm Clinical Study): low-dose radiotherapy
Sponsors
Ordos Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Advanced non-small cell lung cancer was confirmed by pathology; 2. Progression of the disease after receiving chemotherapy or antivascular drugs combined with PD-1 or PD-L1 inhibitors; 3.ECOG performance status score 0-2, age >=18 years old; 4.At least 2 cycles of LD-RT were received to evaluate the efficacy; 5. at least one measurable lesion; 6. Life expectancy >=3 months; 7. Informed consent, signed consent.
Exclusion criteria
Exclusion criteria: 1. Received radiation therapy before; 2.There are contraindications related to radiation therapy; 3. Severe immune-related adverse reactions in the past; 4.A history of pulmonary fibrosis, pulmonary hypertension, or severe airway obstructive disease; 5.Severe, uncontrollable brain or psychiatric symptoms.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective response rate;Overall survival time;mmune cell infiltration in peripheral blood; | — |
Countries
China
Contacts
Public ContactLi Quanfu
Ordos Central Hospital
Outcome results
None listed