Urethral stricture
Conditions
Interventions
Oliceridine group:During anesthesia induction, oliceridine 3 mg (3 mL) was administered intravenously, followed by another 3 mg (3 mL) during skin closure. Intraoperative supplemental doses of oliceri
Sufentanil group:During anesthesia induction, sufentanil 15 µg (3 mL) was administered intravenously, followed by another 15 µg (3 mL) during skin closure. Intraoperative supplemental doses of sufenta
Sponsors
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male patients scheduled for urethral repair and reconstruction surgery under general anesthesia; 2. Aged between 18 and 65 years; 3. American Society of Anaesthesiologists (ASA) physical status classification of I~III; 4. Body Mass Index (BMI) ranging from 18 to 30 kg/m^2; 5. Patients or their authorized family members have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. There are contraindications for the use of oliceridine (such as severe respiratory depression, paralytic ileus, or allergy to oliceridine); 2. Long-term use of opioids or tolerance to opioids; 3. Severe impairment of heart, lung, liver or kidney function; 4. Allergy to other drugs involved in this study; 5. Illiteracy or communication difficulties; 6. Participation in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative 6-hour NRS scale pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-operative static and dynamic pain scores and the incidence of moderate to severe static pain within 24 hours after surgery;The time of the first rescue analgesia after surgery and the number of rescue analgesia administration;Patient satisfaction scores for post-operative analgesia;Post-operative nausea and vomiting (PONV) grading;Post-operative respiratory depression and subclinical respiratory depression;Ramsay sedation score;Post-operative Athens Insomnia Scale (AIS) score;Intra-operative QTc interval;The score of the Europe Health-Related Quality of Life Questionnaire 5 Dimensions (EQ-5D);Time to first ambulation post-operatively;Inflammatory factor;Other adverse events; | — |
Countries
China
Contacts
Public ContactDong Yushan
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed