Bronchoscopy
Conditions
Interventions
Remimazolam group:The patient will receive an intravenous injection of 0.3mg/kg of esketamine, followed by remimazolam 0.2mg/kg 30 seconds later. During the operation, an additional 0.05mg/kg of remim
Propofol group:The patient will receive an intravenous injection of 0.3mg/kg of esketamine, followed by 1.5mg/kg propofol 30 seconds later. During the operation, an additional 0.5mg/kg of propofol wil
Sponsors
Nanjing Drum Tower Hospital Group Suqian Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing fiberoptic bronchoscopy under general anesthesia; 2. ASA grade I-II; 3. Age >= 65 years old.
Exclusion criteria
Exclusion criteria: 1. Combined with mental illnesses and cognitive dysfunction. 2. Long term use of sedative drugs, analgesic drugs,and alcohol. 3. Allergic to remimazolam and ketamine or have contraindications (such as myasthenia gravis, severe hypertension, increased intracranial pressure, hyperthyroidism, etc.). 4. Severe heart, liver and kidney dysfunction.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Time to sedation;Dosage of sedative drugs;Awakening duration;Recovery duration;Hemodynamics;The incidence of adverse events;Satisfaction of endoscopists and patients; | — |
Primary
| Measure | Time frame |
|---|---|
| The success rate of sedation; | — |
Countries
China
Contacts
Public ContactWang Fan
Nanjing Drum Tower Hospital Group Suqian Hospital
Outcome results
None listed