Open-heart surgery under general anesthesia with cardiopulmonary bypass (including coronary artery bypass grafting, valve replacement, aortic replacement, etc.)
Conditions
Interventions
Trial group:Intravenous infusion of remazolam during extracorporeal circulation
Control group:Intravenous propofol infusion during extracorporeal circulation
Sponsors
WeiHai Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–80 years, undergoing cardiac surgery with cardiopulmonary bypass (CPB); 2.ASA Classification: Grade II-IV; 3.BMI range: 18.5-30 kg/m^2; 4.Patients participate voluntarily and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1.Preoperative heart failure, cardiogenic shock; 2.Preoperative long-term use of analgesic and/or psychotropic drugs; 3.Allergy to anesthesia drugs; 4.Chronic renal failure requiring dialysis; 5.Patients with severe pulmonary insufficiency; 6.Severe liver and kidney function disease; 7.Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-sensitivity cardiac troponin T (hs-cTnT);Blood lactate level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation Index;Incidence of adverse events during the perioperative period and within 3 months postoperatively (including sudden death, myocardial infarction, cerebral infarction, acute kidney injury, acute respiratory failure, acute liver failure, etc.).;Urine output;Cerebral oxygen saturation;Glasgow Coma Scale;Alanine aminotransferase / Aspartate aminotransferase;Blood creatinine level; | — |
Countries
China
Contacts
Public ContactGao Haolei
WeiHai Municipal Hospital
Outcome results
None listed