Neuropathic corneal pain (NCP)
Conditions
Interventions
Sponsors
Eye Hospital, Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Neuropathic corneal pain patients: (1) pain-like symptoms (pain, burning, allodynia, etc.): at least 3 items in the Eye Pain Assessment Questionnaire (OPAS), accounting for 30%;(2) in vivo confocal microscopy (IVCM) neurological abnormalities: decreased nerve density, neuroma, dendritic cells;(3) no staining or mild staining of cornea; 2.Dry eye patients: (1) FBUT= 5 s or Schirmer I = 5mm/5min without surface anesthesia, dry eye, foreign body sensation, burning sensation, fatigue, discomfort, vision fluctuation and other subjective symptoms can be diagnosed;(2) 5 s<FBUT=10s or 5mm/5 min< Schirmer I =10 mm/5min without topical anesthesia, dry eye, foreign body sensation, burning sensation, fatigue, discomfort, vision fluctuation and other subjective symptoms, while cornea and conjunctiva fluorescein staining positive, dry eye can be diagnosed. 3.Able to cooperate with the completion of various checks; 4.Giving informed consent for this study;
Exclusion criteria
Exclusion criteria: 1.Keratopathy; 2.Long-term wear of contact lenses; 3.Glaucoma complicated with poor intraocular pressure control; 4.Corneal trauma; 5.History of corneal surgery; 6.Previous cranial nerve injury surgery; 7.Involuntary participants in this study; 8. Autoimmune diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of nerve branches;Corneal nerve density; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dendritic cell density;Curvature of nerve; | — |
Countries
China
Contacts
Public ContactQi Dai
Eye Hospital, Wenzhou Medical University
Outcome results
None listed