Preoperative anxiety
Conditions
Interventions
:Treatment of anxiety with 2 sprays of dexmedetomidine nasal spray (total 50 µg)
Normal saline nasal spray control group (Group C):Two sprays of normal saline nasal spray for the treatment of anxiety (placebo effect)
Sponsors
Weifang People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with American Society of Anesthesiologists (ASA) physical status class I to III (I for healthy,II for mild systemic disease,III for severe systemic disease); 2. Between 18 and 65 years old; 3. Preoperative anxiety (HAMA anxiety scale score >=14); 4. Uterine surgery (hysterectomy, myomectomy)
Exclusion criteria
Exclusion criteria: 1. The patient refused to participate in the study; 2. History of allergy to dexmedetomidine or other a2 adrenergic receptor agonists; 3. Diagnosis or suspicion of sleep apnea; 4. History of alcohol dependence or drug abuse (especially sedatives, hypnotics, opioids, etc.); 5. suffering from mental or neurological disorders; 6. Severe bradycardia; 7. Patients with second-degree type ? and third-degree conduction block; 8. Abnormal nasal anatomy or inflammation/infection of nasal cavity and paranasal sinuses.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Anxiety Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of adverse reactions after drug use;Incidence of postoperative agitation in two groups of patients;Intraoperative consumption of propofol and remifentanil;The amount of etomidate consumed when the patient's consciousness disappears during anesthesia induction.;Athens Insomnia Scale score;Intraoperative hemodynamic indicators: mean arterial pressure, heart rate, and bispectral index of electroencephalogram;The number of additional administrations of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactBao Lang
Weifang People's Hospital
Outcome results
None listed