Severe oligospermia
Conditions
Interventions
Group A (Part One):None
Group B (Part One):None
Group A (Part Two):Seminal vesiculoscopy surgery treatment
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Group A and Group B: Males aged 20-50; height 165cm-180cm; 2. Group A: Married, with a desire for fertility, and has not conceived naturally for more than 1 year; 3. Group A: After conservative drug treatment, semen was tested a total of 4 times (twice before and twice after drug treatment), semen volume >1.5ml, progressive motile sperm <10% each time, total progressive sperm count <10 ×10^6; 4. Group A: Seminal vesicle MRI shows significant dilation of the seminal vesicle ducts; 5. Voluntarily signed informed consent, understands and accepts potential surgical risks and complications, and agrees to postoperative timely follow-up; understands and accepts MRI examination; 6. Group B: Married and has conceived naturally within the past five years.
Exclusion criteria
Exclusion criteria: 1. Urinary system infections: Symptoms of urinary tract infection (such as urinary irritation symptoms, prostatitis symptoms, hematospermia, etc.) or abnormal white blood cells or red blood cells indicated in routine urinalysis; 2. Organic abnormalities: Abnormal development of external genitalia, including significant abnormalities of the penis, scrotum, testes, epididymis, or spermatic cord, as well as organic diseases of the lumbar region; 3. Systemic diseases: Patients with psychiatric disorders, endocrine diseases, neurological diseases, or severe cardiovascular diseases, including hypertension, hypotension, diabetes, hyperthyroidism, hypothyroidism, epilepsy, and gonadal dysfunction; abnormal liver or kidney function, abnormal coagulation indicators, etc.; 4. History of pelvic surgery; 5. Subjects deemed by the investigator as unsuitable for participation in this clinical study (subjects who prefer assisted reproductive technology).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| semen parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate of partner;Seminal vesicle size;Seminal plasma biochemistry; | — |
Countries
China
Contacts
Public ContactSong Tao
Nanjing Drum Tower Hospital
Outcome results
None listed