Knee Replacement
Conditions
Interventions
Sufentanil group:Sufentanil was given for PCIA.
Low-dose tegoridine group:A low dose of Tegillidine was given for PCIA.
High-dose tegoridine group:A high dose of Tegillidine was given for PCIA.
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years old, including cut-off values, gender is not limited; 2. Elective general anesthesia descending unilateral knee arthroplasty; 3. American Society of Anesthesiologists (ASA) rating I-III; 4. Able to understand pain intensity assessment methods; 5. Subjects understand the purpose and steps of this trial, voluntarily participate in this trial, and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Undergoing any clinical trial within 28 days before surgery; 2. Body mass index (BMI) 30 kg/m^2; 3. Allergy to opioids; 4. Allergy or contraindication to anesthesia, adjuvant analgesia, salvage analgesics, rescue antiemetics, antibiotics used in the study; 5. History of acute and chronic bronchial asthma; 6. Diagnosis or suspicion of sleep apnea syndrome; 7. Long-term opioid therapy; 8. Use of any painkillers before surgery; or long-term NSAIDs; 9. Use of drugs that affect analgesic response before surgery; 10. Abnormal liver and kidney function; 11. Prolongation of the Q-T interval of electrocardiogram; 12. Patients will be excluded if they have psychiatric or neurological diseases, gastrointestinal obstruction, chronic obstructive pulmonary disease, or pulmonary heart disease, and cardiovascular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SPID; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of subjects who did not receive remedial analgesic treatment during the treatment period;Total dose of remedial analgesic drugs received during the treatment period;PCIA pump press total times and effective press times; | — |
Countries
China
Contacts
Public ContactLu Yi
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed