Infectious disease
Conditions
Interventions
Sponsors
QingHai University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients admitted to ICU over 18 years of age; 2.Patients with a confirmed diagnosis of infection who require treatment with meropenem, piperacillin/tazobactam, ceftazidime; 3.Patients able to receive medication by the intravenous route;
Exclusion criteria
Exclusion criteria: 1.Patients with allergies to meropenem, piperacillin/tazobactam, ceftazidime; 2.Pregnant and lactating women; 3.Patients enrolled in other clinical trials; 4.Patients who do not cooperate and refuse to participate; 5.Meropenem, ceftazidime for intrathecal injection in patients with;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 50%ft>MIC,100%ft>MIC;PK parameters: Cmax, Cmin, T1/2, CL, Vd;PD Parameter: Minimum Inhibitory Concentration (MIC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in Bacterial Resistance;Evaluation of Antibiotic Efficacy;Incidence of adverse reactions to ß-lactam antibiotics; | — |
Countries
China
Contacts
Public ContactYabin Duan
QingHai University Affiliated Hospital
Outcome results
None listed