Postoperative pain
Conditions
Interventions
Liposomal Bupivacaine Quadratus Lumborum Block Group:0.44% bupivacaine liposomal bilateral quadratus lumbarum block, 30 ml on each side
Epidural Morphine group:10 ml of normal saline solution containing 2 mg of morphine through the epidural catheter
Sponsors
Jiangsu Province People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 or above; 2. ASA I to III; 3. Patients who underwent elective subarachnoid block anesthesia cesarean section for full-term pregnancy; 4. Patients who can understand the content of the score, complete the questionnaire and follow the study protocol.
Exclusion criteria
Exclusion criteria: 1. Patients with neuropathy or chronic pain syndrome in the past; 2. Patients with a history of allergy to local anesthetics or one of the study drugs (liposomal bupivacaine, acetaminophen and butofino tartrate); 3. Patients with severe liver and kidney insufficiency (Child-Pugh score grade C or above or creatinine value > 1.5 times the upper limit of normal or GFR < 40ml/min); 4. Patients with mental or cognitive impairment; 5. History of drug or alcohol abuse, including long-term opioid use; 6. Those with contraindications to quadratus lumborum block and subarachnoid block (including puncture site infection, bleeding tendency, allergy to local anesthetics, refusal, anatomical abnormalities, hemodynamic instability, and known neurological diseases); 7. Patients using anticoagulants or aspirin; 8. Patients with a history of gastrointestinal ulcers; Patients with cardiac disease in the mother and infant (including severe arrhythmias, myocarditis, ischemic heart disease, valve disease, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cumulative opioid consumption, expressed as morphine equivalent dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of analgesic pump pressing times and morphine consumption equivalents;NRS scores during rest and movement;The first time an interval of intravenous supplemental analgesia is required;Brief Pain Inventory scale score at 72h after surgery;Time to first spontaneous voiding;First time to get out of bed successful;Incidence of adverse events (including somnolence, respiratory depression, nausea, vomiting, pruritus, urinary retention, hypotension, and puncture site hematoma); | — |
Countries
China
Contacts
Public ContactMa Rong
Jiangsu Province People's Hospital
Outcome results
None listed