Major Depressive Disorders
Conditions
Interventions
MDD and Health Control Group:none
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: MDD: (1) Meet the diagnostic criteria for "major depressive disorder" as outlined in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5); (2) HAMD-17 score >= 14 points; (3) Age 18–65 years; (4) First episode; (5) No prior use of any psychiatric medications, or no psychiatric medication treatment within the past 14 days; (6) Planned use of a single type of antidepressant medication; (7) Right-handed; (8) Patient and family members have signed an informed consent form. Healthy control: (1) healthy people matched with the sex, age and education level of the case group; (2) Han nationality; (3) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: MDD: (1) Currently or previously diagnosed with a mental disorder other than depressive disorder according to DSM-5 criteria; (2) History of severe organic diseases or conditions affecting major systems or organs; (3) Pregnant or breastfeeding women; (4) Received physical therapy within the past 3 months; (5) Participated in an interventional clinical trial within the past 3 months; (6) Presence of electronic or metallic implants in the body; (7) Transitioned to a manic phase during follow-up; (8) Participants deemed by the investigator to have poor compliance or unsuitability for the study. Healthy control: (1) having serious physical diseases and brain organic diseases; (2) having any mental disorder in DSM-5; (3) have a family history of mental illness or suicide; (4) Suicidal behavior in the past or suicidal thoughts at present; (5) Refusing to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Suicide Ideation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression severity;Anxiety severity;Anhedonia; | — |
Countries
China
Contacts
Public ContactTian Xue
Tianjin Anding Hospital
Outcome results
None listed