Central retinal artery occlusion
Conditions
Interventions
Intervention group:Patients meeting the inclusion criteria for CRAO will all receive USMB therapy in combination with standard supportive care.
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–70 years, first episode of CRAO, with onset 72h < t <= 14d; 2.Fundoscopy reveals a cherry-red spot, and FFA (fundus fluorescein angiography) shows absence of central retinal artery filling; 3.BCVA (best-corrected visual acuity): Light perception to 20/400, with visual field <=10° (Goldmann perimetry); 4.Patient is conscious, capable of normal communication, and voluntarily provides signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Concurrent uveitis or corneal edema impairing ultrasound transmission. 2. Use of antiplatelet or anticoagulant medications within the past 3 months (requires discontinuation for >=7 days prior to enrollment). 3. Presence of psychiatric disorders or cognitive impairment preventing informed consent or completion of the study protocol. 4. Severe hepatic or renal dysfunction (liver or kidney function parameters exceeding twice the upper limit of normal), uncontrolled hypertension (systolic blood pressure >=180 mmHg and/or diastolic blood pressure >=110 mmHg), or severe diabetic complications (e.g., diabetic nephropathy stage IV, diabetic foot ulcers, etc.). 5. Known hypersensitivity to ultrasound contrast agents or other study-related medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual and Functional Assessment Indicators (Best Corrected Visual Acuity, BCVA; Visual Field Range; Vision-Related Quality of Life Score);Imaging Indicators (Fluorescein Angiography, FFA; Retinal Blood Flow Density, BFD; Retinal Nerve Fiber Layer Thickness, RNFL; Electroretinography, ERG);Biomarker Indicators (Nitric Oxide, NO; Endothelial Nitric Oxide Synthase, eNOS levels in aqueous humor and serum);Vision; | — |
Countries
China
Contacts
Public ContactHe peng
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed