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Analgesic effect of hydromorphone combined with ropivacaine during paravertebral nerve block in thoracic surgery

Analgesic effect of hydromorphone combined with ropivacaine during paravertebral nerve block in thoracic surgery

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500109930
Enrollment
Unknown
Registered
2025-09-26
Start date
2025-10-15
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary disease requires thoracoscopic lobectomy

Interventions

PR group:0.2%Ropivacaine was used forT4-5?T7-8 paravertebral nerve block
PRH group:0.2% Ropivacaine and 5ug/kg Hydromorphone was used forT4-5?T7-8 paravertebral nerve block

Sponsors

Hainan General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. ASA grades I-III,; 2. aged 20-70 years; 3. underwent elective thoracoscopic lobectomy. 4. The patients had no history of cardiovascular disease, sinus bradycardia, sinus node dysfunction, severe arrhythmia, or thoracic deformities.

Exclusion criteria

Exclusion criteria: 1. Known chronic pain and opioid use; 2. Local anesthetic allergy; 3. History of dementia, mental illness, or other central nervous system disorders or drug dependence, with poor compliance; 4. Video-assisted thoracoscopic lobectomy or conversion to thoracotomy was not performed under general anesthesia;

Design outcomes

Primary

MeasureTime frame
First time to apply the analgesic pump after surgery;VAS scores and Ramsay scores;

Secondary

MeasureTime frame
Intraoperative consumption of remifentanil;Intraoperative Methoxymine Dosage;Intraoperative Methoxymine Dosage;hypotension;PONV;Respiratory depression (SPO2 less than 85%);urinary retention;Blood pressure fluctuation value;pruritus;astriction;shiver;Time of first feeding after surgery;The first time to get out of bed after surgery;Number of analgesic pump compressions;

Countries

China

Contacts

Public ContactGao Wei

Hainan General Hospital

gaowei20055@126.com+86 898 68642232

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026