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Comparison of the analgesic effect, incidence of delirium, anxiety and depression between bupivacaine liposome intercostal nerve block and PCIA in patients undergoing thoracoscopic surgery

Comparison of the analgesic effect, incidence of delirium, anxiety and depression between bupivacaine liposome intercostal nerve block and PCIA in patients undergoing thoracoscopic surgery

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500109926
Enrollment
Unknown
Registered
2025-09-26
Start date
2025-08-03
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracoscopic wedge resection was performed

Interventions

Experimental Group:The method of anesthesia in this study was rapid induction of double-lumen endotracheal intubation and intravenous inhalation combined anesthesia. Sublobar resection (wedge or segme
Control group:The control group was treated with a common intravenous analgesia pump consisting of opioids (sufentanil 0.8µg/kg) and central antiemetic (palonosetron 0.5 mg), nalbuphine 0.8 mg/kg, and
Single compression volume: 0.5 mL. Nalbuphine 1 mg was given 20 min before the end of surgery, and then the postoperative intravenous analgesia pump was continuously pumped. In the experimental group,

Sponsors

The Affiliated Hospital of Guizhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients scheduled for pulmonary surgery under general anesthesia with double-lumen bronchial intubation; 2.Age >= 18 years old; 3. American Society of Anesthesiologists Health Classification (ASA Surgical Classification) Grade I/II/III; 4.Those who can participate in cognitive function assessment and obtain informed consent.

Exclusion criteria

Exclusion criteria: 1.Patients with missing case data: 2. Patients with a preoperative Mini-Mental State Examination (MMSE) score of less than 20 points; 3.Patients with a history of psychosocial disorders or the use of psychotropic drugs; 4. Patients with any central nervous system diseases; 5. Those who are unable to communicate due to aphasia, severe hearing impairment or other difficulties; 6. Those with neurological and mental disorders such as dementia, language disorders, or psychological problems that prevent them from collaborating with the survey participants; 7. Those with a history of alcohol abuse or acetylcholine use; 8. Severe circulatory system diseases (such as severe arrhythmia, hypertension, coronary artery disease, heart failure) and history of cardiac surgery; 9. Severe respiratory system diseases (respiratory failure, severe chronic obstructive pulmonary disease);

Design outcomes

Primary

MeasureTime frame
Postoperative NRS pain score;

Secondary

MeasureTime frame
Hamilton Depression Scale score;Hamilton Anxiety Scale score;

Countries

China

Contacts

Public ContactTan li

The Affiliated Hospital of Guizhou Medical University

tldctoph@163.com+86 139 8511 3579

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026