schizophrenia
Conditions
Interventions
Observation group:Injection of domestic paliperidone palmitate
Sponsors
The Brain Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Outpatient or inpatient patients with schizophrenia who meet the ICD - 10 diagnostic criteria. (2) Patients in the acute phase or stable phase of the disease. (3) Aged 18 - 65 years old (including the lower limit boundary value), regardless of gender. (4) Subjects and their guardians who have signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients have diagnoses of other mental disorders except schizophrenia. (2) Patients with severe physical diseases, mental retardation, mental disorders caused by organic brain diseases and physical diseases, or other abnormal indicators (AST/ALT = 2 times the upper limit of normal value, Cr > 1.2 times the upper limit of normal value, QTc interval > 450 ms in males and > 470 ms in females). (3) Patients who have ever had or currently have tardive dyskinesia (TD), neuroleptic malignant syndrome (NMS), or severe extrapyramidal adverse reactions. (4) Patients who have had allergic reactions to any antipsychotic drugs in the past. (5) Patients who have been ineffective in treatment with risperidone or paliperidone in the past. (6) Pregnant or lactating women, women planning to become pregnant; or those who cannot ensure to take effective contraceptive measures during the study. (7) Other situations where investigators consider patients unsuitable for clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Syndrome Scale;UKU Side - Effect Rating Scale; | — |
Countries
China
Contacts
Public ContactZhenjuan Qin
The Brain Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed