Skip to content

Research on the Correlation between the Components of Cerebrospinal Fluid and Plasma Omics and the Prognosis of Patients with Traumatic Brain Injury Complicated by Acute Consciousness Impairment

An Observational Study on the Correlation Between Cerebrospinal Fluid and Plasma Omics Biomarkers and Prognosis in Traumatic Brain Injury Patients with Acute Consciousness Disturbance

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500109921
Enrollment
Unknown
Registered
2025-09-26
Start date
2025-10-01
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain injury

Interventions

Sponsors

Jingjiang Province People's Hospital (The First Affiliated Hospital of Nanjing Medical University)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Patients with traumatic brain injury from whom cerebrospinal fluid and plasma samples were collected and preserved at 7 days post-onset; 2.The Glasgow Coma Scale (GCS) score on the day of onset ranged from 3 to 12; 3.Age: 18 to 65 years.

Exclusion criteria

Exclusion criteria: 1.Mortality during hospitalization or follow-up; 2.Do not consent to participate in this study; 3.Concomitant obstructive hydrocephalus; 4.Acute hydrocephalus following brain injury; 5.Concomitant uncontrolled intracranial infection; 6.Concomitant status epilepticus; 7.Concomitant renal insufficiency; 8.History of prior neuropsychiatric disorders; 9.Patients identified during follow-up who developed hydrocephalus and declined ventriculoperitoneal shunting or lumbar cistern drainage.

Design outcomes

Primary

MeasureTime frame
The presence or absence of hydrocephalus;Cognitive function;

Secondary

MeasureTime frame
State of consciousness;Neurological function;

Countries

China

Contacts

Public ContactWang Xi

Jingjiang Province People's Hospital (The First Affiliated Hospital of Nanjing Medical University)

xiwang_199112@163.com+86 25 68303064

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026