Gastrointestinal disease
Conditions
Interventions
Dexmedetomidine nasal spray group:Dexmedetomidine Hydrochloride nasal spray was administered preoperatively
Saline solution group:0.9% sodium chloride nasal spray
Sponsors
The Second Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Schedule a date for a painless gastrointestinal endoscopy; 2. The patient and family are informed and sign the informed consent form; 3. Age between 18-65 years, gender not limited; 4. ASA grade I-II; 5. No significant abnormalities in blood routine, electrocardiogram, and coagulation function results; 6. BMI controlled between 18-30 kg/m^2; no other serious comorbidities.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to or contraindicated for the drugs relevant to this study; 2. Patients with significant impairment of important organ functions such as respiratory, circulatory, or liver and kidney function prior to surgery; 3. Patients with psychological issues or a history of mental illness; 4. Patients deemed to have difficult airway management; 5. Patients who have been taking anesthetics, analgesics, or sedatives long-term; 6. Patients with poorly controlled or untreated hypertension (resting blood pressure exceeding 180/100 mmHg); 7. Patients with severe cardiovascular history (e.g., unstable angina, heart failure, and arrhythmias); 8. Patients with hyperthyroidism; 9. Patients who refuse to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to loss of consciousness (LOC);Recovery Time;hypotension;bradycardia; | — |
Countries
China
Contacts
Public ContactXiaohui Wang
The Second Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed