Acute pancreatitis
Conditions
Interventions
Indomethacin suppository treatment group:NA
Non-indomethacin suppository treatment group:NA
Sponsors
Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 80 years, inclusive. 2. Diagnosis of acute pancreatitis (AP) established by meeting at least two of the following three criteria: (1) Typical upper abdominal pain; (2) Serum lipase or amylase level at least three times the upper limit of normal (ULN); (3) Characteristic findings of AP on abdominal imaging. 3. Onset of abdominal pain symptoms <48 hours prior to inclusion.
Exclusion criteria
Exclusion criteria: 1. Use of any non-steroidal anti-inflammatory drugs (NSAIDs) within 14 days prior to enrollment. 2. History of active peptic ulcer or gastrointestinal bleeding within 30 days prior to enrollment. 3. Pregnancy or lactation. 4. Severe renal dysfunction, defined as a baseline serum creatinine level >1.5 times the upper limit of normal (ULN). 5. Severe hepatic dysfunction, evidenced by clinically significant liver disease at baseline, such as cirrhosis or acute liver failure. 6. Known history of hypersensitivity to NSAIDs. 7. New-onset, exacerbation, or uncontrolled hypertension within 30 days prior to enrollment. 8. History of a major adverse cardiovascular or cerebrovascular event (e.g., severe heart failure, myocardial infarction, or stroke) within 180 days prior to enrollment. 9. Pancreatitis caused by malignancy or post-Endoscopic Retrograde Cholangiopancreatography (ERCP) pancreatitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The occurrence of organ failure within 7 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality within 30 days;Length of hospital stay;Intensive care unit (ICU) admission;Length of stay in the ICU;Total hospitalization costs;Late local complications: development of pancreatic pseudocyst or walled-off necrosis diagnosed between 30 and 60 days after time zero;Peak serum C-reactive protein (CRP) level within the first 7 days; | — |
Countries
China
Contacts
Public ContactDong Wu
Peking Union Medical College Hospital
Outcome results
None listed