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Effect of sleep disorders in late pregnancy on expression of inflammatory factors in central nervous system

Effect of sleep disorders in late pregnancy on expression of inflammatory factors in central nervous system

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500109887
Enrollment
Unknown
Registered
2025-09-26
Start date
2025-10-17
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain

Interventions

Sleep disorder group (SD group):None
No sleep disorder group (NSD group):None

Sponsors

Jinan Maternal and Child Health Care Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1.Full-term pregnancy; 2.Singleton pregnancy; 3.Contraindications for lumbar epidural anesthesia include coagulation abnormalities, anticoagulant therapy, severe hypovolemia or hemodynamic instability; 4.Planned cesarean section.

Exclusion criteria

Exclusion criteria: 1.Previous mental illness, central nervous system disease, liver disease, renal dysfunction, cardiopulmonary dysfunction; 2.Serious obstetric complications, such as placenta previa or placental abruption; 3.BMI>35; 4.No other clinical studies have been participated in for the past 6 months; 5.Patients refuse to participate.

Design outcomes

Primary

MeasureTime frame
expression of IL-1ß?IL-6?IL-10?IL-18?TNF-a incentral nervous system;

Secondary

MeasureTime frame
Sleep duration within 48h after surgery;Postoperative complications;Area under the pain curve of VAS score within 48 hours after cesarean section;Proportion of using indomethacin suppository;Postoperative incidence of postpartum depression at 1, 3 and 6 months;VAS score of 6h?12h?24h?48h after sugery;Postoperative incidence of chronic pain at 1, 3 and 6 months;Proportion of pressing analgesia pump;

Countries

China

Contacts

Public ContactMeng Fanqing

Jinan Maternal and Child Health Care Hospital

mengfanqing8211@126.com+86 531 89029618

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026