Postoperative pain
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Full-term pregnancy; 2.Singleton pregnancy; 3.Contraindications for lumbar epidural anesthesia include coagulation abnormalities, anticoagulant therapy, severe hypovolemia or hemodynamic instability; 4.Planned cesarean section.
Exclusion criteria
Exclusion criteria: 1.Previous mental illness, central nervous system disease, liver disease, renal dysfunction, cardiopulmonary dysfunction; 2.Serious obstetric complications, such as placenta previa or placental abruption; 3.BMI>35; 4.No other clinical studies have been participated in for the past 6 months; 5.Patients refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| expression of IL-1ß?IL-6?IL-10?IL-18?TNF-a incentral nervous system; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep duration within 48h after surgery;Postoperative complications;Area under the pain curve of VAS score within 48 hours after cesarean section;Proportion of using indomethacin suppository;Postoperative incidence of postpartum depression at 1, 3 and 6 months;VAS score of 6h?12h?24h?48h after sugery;Postoperative incidence of chronic pain at 1, 3 and 6 months;Proportion of pressing analgesia pump; | — |
Countries
China
Contacts
Jinan Maternal and Child Health Care Hospital