Sedation and analgesia
Conditions
Interventions
Observation group:None
Sponsors
Shanghai Fourth People's Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Requires admission to ICU; 3. Mechanically ventilated patients receiving combined analgesia and sedation treatment with remifentanil and propofol; 4. Family members agree to participation in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of severe cranial brain injury (defined as GCS score < 8) or status epilepticus (defined as seizures lasting more than 5 minutes or failure to regain consciousness between two seizures), which may affect the interpretation of EEG signals; 2. Known allergy to Remifentanil or Dexmedetomidine; 3. Severe liver failure (Child-Pugh class C) or end-stage renal disease (eGFR < 15 mL/min/1.73 m^2); 4. Pregnant or breastfeeding women; 5. Patients who voluntarily withdraw from treatment or die during the study; 6. Other conditions deemed unsuitable for participation in this study by the investigator, such as the presence of severe mental illness that impairs the ability to cooperate with assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between EEG grading and RASS score; | — |
Countries
China
Contacts
Public ContactZongping Fang
Shanghai Fourth People's Hospital Affiliated to Tongji University
Outcome results
None listed