Depression
Conditions
Interventions
Observation group:None
Sponsors
Beijing Anding Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Gender: No restriction. Age: >= 18 years old and = 18; No contraindications identified through the Transcranial Magnetic Stimulation Adult Safety Screen (TASS) questionnaire; Understand and voluntarily participate in this study, be able to comply with the treatment protocol, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Meet the diagnostic criteria for other mental disorders in DSM-5, including but not limited to: neurodevelopmental disorders, bipolar and related disorders, anxiety disorders, obsessive-compulsive and related disorders, schizophrenia spectrum and other psychotic disorders, substance-related and addictive disorders, and personality disorders; Treatment-resistant depression: Major depressive disorder that has failed to respond to treatment with two or more antidepressants at adequate doses and for adequate durations; A history of or current clinically significant severe physical illness, such as severe or unstable diseases of the cardiovascular, respiratory, digestive, endocrine, urinary, hematological, or nervous systems, or any other condition that the researcher deems may pose potential risks to the patient's safety or ability to fully participate in the study; Any severe neurological disease or impairment, including but not limited to: any disease potentially associated with increased intracranial pressure, space-occupying brain lesions, a history of seizures (except those induced by ECT treatment), cerebral aneurysms, Parkinson's disease, Huntington's disease, multiple sclerosis, and severe head trauma with loss of consciousness; A score of greater than 3 on the third item (suicide-related item) of the 17-item Hamilton Depression Rating Scale (HAMD-17); Having received physical treatments such as systematic modified electroconvulsive therapy (MECT), transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), or vagus nerve stimulation (VNS) within 3 months prior to screening; Females who are pregnant or lactating; or females of childbearing potential who are unwilling to use contraceptive methods during the study period; Contraindications to magnetic resonance imaging (MRI), such as having metal or electronic devices implanted in the body (e.g., intracranial metal foreign bodies, cochlear implants, cardiac pacemakers, and stents); Having participated in or currently participating in other interventional clinical trials within the past 30 days; Any other conditions that the researcher deems make the individual unsuitable for participating in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The reduction score of the 17-item Hamilton Depression Rating Scale (HAMD-17) after the end of treatment compared with the baseline period; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of response;Rate of remission; | — |
Countries
China
Contacts
Public ContactWang Zhimin
Beijing Anding Hospital Affiliated to Capital Medical University
Outcome results
None listed