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Comparison of Tamoxifen versus Mitomycin C to Prevent Recurrence After Internal Optical Urethrotomy: A Randomized Controlled Trial.

Comparison of Effectiveness of Tamoxifen and Mitomycin C in Prevention of Recurrent Urethral Stricture Following Internal Optical Urethrotomy (IOU) - TAM-MMC after IOU

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500109869
Enrollment
Unknown
Registered
2025-09-26
Start date
2025-01-17
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior urethral stricture disease

Interventions

Group A (Tamoxifen):Oral tamoxifen 10 mg twice daily for 6 months, starting immediately after internal optical urethrotomy (IOU). 16 Fr Foley catheter placed for 5–7 days post-surgery.
Group B (Mitomycin C):Single intraoperative intralesional injection of mitomycin C (10 mg/mL) at the urethrotomy site. 16 Fr Foley catheter placed for 5–7 days post-surgery.

Sponsors

Hayatabad Medical Complex, Peshawar, KPK, Pakistan
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 66 Years

Inclusion criteria

Inclusion criteria: 1. Male, >=18 years; 2. Anterior urethral stricture =12; 5. Provided written informed consent.

Exclusion criteria

Exclusion criteria: 1. Posterior urethral stricture; 2. Previous urethral surgery other than IOU; 3. Active urinary tract infection; 4. Urethral malignancy; 5. Uncontrolled comorbidities. 6. Contraindications to study drugs

Design outcomes

Primary

MeasureTime frame
International Prostate Symptom Score (IPSS);—

Secondary

MeasureTime frame
Maximum urinary flow rate (Qmax);Stricture dimensions;—

Countries

Pakistan

Contacts

Public ContactSaifullah Khan

Institute of kidney diseases, Hayatabad Medical Complex, Peshawar

saify2011@gmail.com+92 345 9182228

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026