Laparoscopic hysterectomy
Conditions
Interventions
group A:loading dose 0.5mg of taglidine fumarate
group B:loading dose 0.75mg of taglidine fumarate
group C:loading dose 1mg of taglidine fumarate
group D:loading dose 3mg morphine
Sponsors
Anqing Municipal Hospital,
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective laparoscopic total hysterectomy 2. ASA I–II 3.Patient age >= 18 years and = 4 at any time within 4 hours post-surgery
Exclusion criteria
Exclusion criteria: 1. Pre-surgery severe cardiac, hepatic, or renal dysfunction 2. Concurrent sleep apnoea syndrome 3. Chronic opioid use, chronic non-steroidal anti-inflammatory drug use, or opioid use within 48 hours prior to surgery 4. Concurrent use of other medications affecting opioid efficacy (e.g., antiepileptics, antidepressants, antipsychotics) 5. Oral or injectable corticosteroids within the preceding three months 6. Abnormal electrocardiogram showing QT interval prolongation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting and exercise VAS pain scores at 6, 12, 18, and 24 hours post-administration of the experimental drug loading dose in four patient groups.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age, gender, BMI, ASA classification, operation time,anesthesia time;The time of the first rescue analgesic;The total number of the analgesic pump within 24 hours and the effective pump number ;adverse reaction; | — |
Countries
China
Contacts
Public ContactHao Yujuan
Anqing Municipal Hospital,
Outcome results
None listed