Postoperative Cognitive Dysfunction
Conditions
Interventions
Observational group:None
Sponsors
Yantai Yuhuangding Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years; 2. ASA classification I-III; 3. NYHA cardiac function class I-II; 4. Elective abdominal surgery under general anesthesia, with surgical duration >= 2 h; 5. No neurodegenerative diseases or cognitive impairment preoperatively.
Exclusion criteria
Exclusion criteria: 1. Age < 65 years; 2. ASA classification IV-VI and/or NYHA cardiac function class III-IV; 3. Coexisting neurological disorders; 4. Use of sedative or psychiatric medications within the past 3 months; 5. Patients with significant cardiac, renal, or pulmonary diseases; 6. History of platelet abnormalities; 7. Severe hearing impairment or language communication difficulties; 8. Emergency surgery; 9. Intraoperative cardiac arrest, ventricular fibrillation, or other events requiring resuscitation; 10. Postoperative loss to follow-up (early discharge, voluntary withdrawal, or non-cooperation); 11. Patients requiring long-term postoperative sedative use; 12. Patients developing postoperative complications such as arrhythmia, cerebral infarction, or infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet parameters (including peripheral blood platelet count, mean platelet volume, platelet distribution width, large platelet ratio, and platelet changes);Postoperative 7-day incidence of POCD; | — |
Countries
China
Contacts
Public ContactYu Cuicui
Yantai Yuhuangding Hospital
Outcome results
None listed