Epidural Related Maternal Fever
Conditions
Interventions
ERMF+DEX group:Dexmedetomidine
Non-ERMF group:none
ERMF group:normal saline
Sponsors
Women and Children’s Hospital of Ningbo University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. nulliparous parturients with well healthy status; 2. full-term ,singleton pregnancy; 3. Clinical judgment indicates that the potential benefits of drug treatment will outweigh the potential risks to the fetus and the mother. 4. The parturient voluntarily participated in the study;
Exclusion criteria
Exclusion criteria: 1. Risk factors for fever during labor: obesity (BMI >= 30 kg/m^2), premature rupture of membranes, history of GBS (Group B Streptococcus) infection, upper respiratory tract infection, diabetes, immunodeficiency, anemia, etc. 2. Drug factors: Gestational hypertension (140/90 mmHg). Bradycardia: Postpartum women with a heart rate of <= 55 beats per minute. History of dexmedetomidine allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum inflammatory factors;Postpartum fever rate;ALKBH5 and mitochondrial autophagy markers;Cell pyroptosis markers; | — |
Countries
China
Contacts
Public ContactShen Yanping
Women and Children’s Hospital of Ningbo University
Outcome results
None listed