A Randomized Controlled Trial of Blood Flow Restriction Combined with Functional Training on Activities of Daily Living, Balance, and Gait Stability in Patients with Parkinson's Disease

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500109830

Enrollment

Unknown

Registered

2025-09-25

Start date

2025-09-30

Completion date

Unknown

Last updated

2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

Blood Flow Restriction Combined with Functional Training Group:The intervention protocol for the "Blood Flow Restriction + Functional Training" group (BFR+Func group) in this study was implemented as

cuffs were completely deflated during the 60-second rest intervals between sets. The functional training focused on improving activities of daily living, dynamic balance, and gait stability, including

if it exceeded 14, task difficulty was reduced or rest was provided. Throughout the intervention, heart rate, RPE, and any adverse events were strictly monitored to ensure safety and tolerability of t

Functional Training Group:The intervention protocol for the "Functional Training" group (Func group) in this study was implemented as follows: Patients in this group received a supervised training pr

Eligibility

Sex/Gender

All

Age

35 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with Parkinson's disease (Hoehn & Yahr stages 1–3, assessed during "ON" phase); aged 35–65 years; capable of independent walking for >= 10 meters; stable anti-Parkinson medication dosage for >= 2 weeks prior to enrollment; MMSE score >= 24; and having provided signed informed consent.

Exclusion criteria

Exclusion criteria: Individuals with moderate to severe depression or other psychiatric disorders; comorbid neurological or musculoskeletal diseases; unstable cardiovascular or metabolic conditions; contraindications to BFR training (e.g., deep vein thrombosis, anticoagulant therapy, etc.); severe motor limitations (e.g., DBS implantation, significant "ON-OFF" fluctuations); participation in structured exercise programs or clinical trials within the past 3 months; or any other health issues that may compromise safe participation in the training.

Design outcomes

Primary

Measure	Time frame
Schwab & England Activities of Daily Living Scale (S&E);Self-Reported Barthel Index (SRBI);Mini-Balance Evaluation Systems Test (Mini-BESTest);Timed Up and Go Test (TUG);6-Minute Walk Test (6MWT);	—

Secondary

Measure	Time frame
Gait Speed;Step Length;Step Time;Coefficient of Variation of Gait Speed;Coefficient of Variation of Step Length;Coefficient of Variation of Step Time;	—

Countries

China

Contacts

Public ContactBaochen Wang

Tianjin University of Sport

wangbc2560@163.com+86 138 2066 2560

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026