T2DM
Conditions
Interventions
Observation Group:This study is an observational study and does not intervene in clinical diagnosis and treatment. It refers to Chapter 9 of the "Guidelines for the Prevention and Treatment of Diabete
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1) Age between 18 and 70 years old, regardless of gender; (2) Clinically diagnosed with type 2 diabetes (refer to the 'Chinese Diabetes Prevention and Treatment Guidelines (2024 Edition)'); (3) Estimated glomerular filtration rate eGFR <= 89 ml/(min×1.73m^2); (4) Clinical physician's judgment that the patient is suitable for treatment with prandial glucagon-like peptide-1 receptor agonist; (5) Voluntary participation in the study and signing of informed consent.
Exclusion criteria
Exclusion criteria: Exclusion Criteria(1) Moderate to severe renal impairment (eGFR = 3 times the upper limit of normal;(3) Individuals with uncontrolled or poorly controlled hypertension (systolic >= 160 mmHg and/or diastolic >= 100 mmHg);(4) Patients with anemia (generally adult males Hb < 120 g/L, adult females Hb < 110 g/L);(5) Acute or chronic metabolic acidosis, including diabetic ketoacidosis;(6) History of severe allergy to canagliflozin, its excipients, or any component of other SGLT-2 inhibitors;(7) Currently participating in or have participated in any other clinical trials within the last month;(8) Considered unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycated hemoglobin (HbA1c); | — |
Secondary
| Measure | Time frame |
|---|---|
| Estimated Glomerular Filtration Rate;Fasting Blood Glucose;Body Mass Index; | — |
Countries
China
Contacts
Public ContactMiao Zhang
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed