somatic cough disorder
Conditions
Interventions
Test Group:Milnacipran Pharmacotherapy
Sponsors
ShangHai Tongji Hospita
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Before any assessment is conducted, the patient or their legal representative must sign an informed consent form; (2) Aged between 18 and 70 years old (inclusive), with no restriction on gender; (3) Meeting the diagnosis of somatoform cough disorder.
Exclusion criteria
Exclusion criteria: (1) Pregnant or lactating women, or those who refuse to sign the informed consent form; (2) Current smokers or those who have quit smoking for <= 2 years; (3) Those with a history of respiratory tract infection within 8 weeks; (4) Those with hepatic or renal insufficiency; (5) Those with a known allergy to milnacipran; (6) Patients taking non-selective MAO inhibitors, selective MAO-B inhibitors, cardiac glycosides, or 5HT1D agonists; (7) Patients with severe psychotic disorders or substance dependence (including: bipolar affective disorder, schizophrenia, and those with manifestations such as mania or suicidal attempts); (8) Patients with severe hypertension, cardiovascular and cerebrovascular diseases, autoimmune diseases, or allergic reactions; (9) Patients with organic brain damage or ataxia; (10) Patients with dysuria or a history of dysuria, glaucoma or increased intraocular pressure, and those with convulsive diseases (such as epilepsy) or a history of such diseases; (11) Patients with a previous bleeding disorder who are also taking anticoagulants (e.g., non-steroidal anti-inflammatory drugs, aspirin, and other drugs that may increase the risk of bleeding); (12) Other circumstances deemed by the researcher to make the individual unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough Visual Analog Scale;Cough Symptom Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Somatic Symptom Disorder - B Criteria Scale;Multidimensional Depression Inventory (MDI);Leicester Cough Questionnaire (LCQ);Generalized Anxiety Disorder-7 (GAD-7);Results of Capsaicin Cough Sensitivity Test;Results of Sputum Supernatant Test (Induced Sputum); | — |
Countries
China
Contacts
Public ContactWu Heng
ShangHai Tongji Hospita
Outcome results
None listed