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Mechanism of personalized dietary intervention on improving metabolic dysfunction-associated fatty liver disease (MAFLD) based on gut microbiota and multi-omics approaches

Mechanism of personalized dietary intervention on improving metabolic dysfunction-associated fatty liver disease based on gut microbiota and multi-omics approaches

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500109819
Enrollment
Unknown
Registered
2025-09-25
Start date
2025-09-30
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic associated fatty liver disease(MAFLD)

Interventions

Control Group:Provide exercise guidance and behavior modification recommendations
Nutritional Intervention Group:Personalized dietary intervention

Sponsors

Hangzhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Confirmed diagnosis of metabolic dysfunction-associated fatty liver disease (MAFLD); 2.Aged 18 to 65 years; 3.Voluntarily signed informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with concurrent liver diseases, including drug-induced liver injury, autoimmune hepatitis, or viral hepatitis; 2.Severe dysfunction of major organs; 3.Contraindications to physical activity; 4.Psychiatric disorders affecting compliance or data reliability; 5.Use of hepatoprotective agents or weight-loss medications within 1 month prior to enrollment; 6.Special populations: infants, children/adolescents, pregnancy, or lactation.

Design outcomes

Primary

MeasureTime frame
Efficacy Outcome Measures;—

Secondary

MeasureTime frame
Safety Outcome Measures;Baseline observation measures;—

Countries

China

Contacts

Public ContactFu Xiaodan

Hangzhou First People's Hospital

fxdnjmu@163.com+86 571 56005600

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026