Uterine Fibroids
Conditions
Interventions
Observation group (Patients with infection events during the perioperative period):None
Control group (Patients without infection events during the perioperative period):None
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria:?? Females aged 18–65 years meeting indications for gynecological surgery (e.g., myomectomy, total hysterectomy, etc.). No preoperative evidence of infection (e.g., respiratory, urinary, or reproductive tract infections), with normal laboratory results (complete blood count, urinalysis, C-reactive protein [CRP], etc.). ?2. Surgical Requirements:?? Patients undergoing gynecological surgery (laparotomy, laparoscopy, or hysteroscopy) with an operative duration >= 30 minutes. Postoperative hospital stay >= 3 days to facilitate infection monitoring. ?3. Ethics and Informed Consent:?? All participants provided written informed consent, and the study was approved by the hospital’s Institutional Review Board (IRB).
Exclusion criteria
Exclusion criteria: 1.Comorbidities Interference:?? Severe cardiac, hepatic, or renal dysfunction; 2.Immunodeficiency (e.g., HIV-positive status, long-term immunosuppressant use) or coagulation disorders. ?2. Infection-Related Exclusions:?? Uncontrolled preoperative infections (e.g., pneumonia, urinary tract infection) or latent infections. ?3. Special Population Exclusions:?? Pregnant or lactating women (potential impact on immune status). ?4. Obesity or Malnutrition:?? BMI >= 30 or malnourished patients (may confound infection risk analysis). ?5. Other Interfering Factors:?? Loss to follow-up or incomplete postoperative data. ?6. Prior Pelvic Interventions:?? History of pelvic surgery or radiotherapy (may alter local microenvironment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antimicrobial consumption (cumulative DDDs), length of hospital stay, and antimicrobial use density (DDD/100 patient-days) in patients with perioperative infections;Preoperative inflammatory markers;Preoperative metabolic and immune status; | — |
Countries
China
Contacts
Public ContactGuo Chunlian
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed