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Association of B-cell Subsets and Functional Alterations with Prognosis in Treatment-Refractory NSCLC Patients Following Immune Checkpoint Inhibitor Therapy

Alterations in B-cell subsets and function and their association with treatment outcomes in non-small cell lung cancer patients with multiline treatment failure after immunotherapy

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500109768
Enrollment
Unknown
Registered
2025-09-24
Start date
2024-01-09
Completion date
Unknown
Last updated
2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

Observation group:NA

Sponsors

The Fifth Affiliated Hospital of Guangzhou Medical University.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients with advanced non-small cell lung cancer who visited our department in 2023 and were eligible for platinum-based chemotherapy regimens 2. Male or female patients aged 18 years or older 3. Treatment-naive patients with pathologically or cytologically confirmed NSCLC, stage IV disease 4. Patients expected to receive 3-4 cycles of chemotherapy 5. Patients with good compliance to treatment and follow-up.

Exclusion criteria

Exclusion criteria: 1. Patients with pathological type, staging, or survival status that do not meet the inclusion criteria 2. Patients with uncontrolled hypertension, unstable angina, history of myocardial infarction, or symptomatic congestive heart failure within 12 months prior to enrollment, or uncontrolled cardiac arrhythmias; electrocardiogram showing ischemic changes or clinically confirmed valvular heart disease 3. Patients with active bacterial, fungal, or viral infections 4. Pregnant or lactating patients 5. Patients with a history of other active malignancies besides NSCLC prior to enrollment 6. Patients with allergic diathesis or known or suspected hypersensitivity to any study medications 7. Patients with poor compliance 8. Patients deemed inappropriate for participation in this trial by the investigators.

Design outcomes

Primary

MeasureTime frame
Objective Response Rate;

Secondary

MeasureTime frame
Progression-Free Survival;Overall Survival;Proportion and Functional Status of B Cell Subsets;

Countries

China

Contacts

Public ContactGuifen Yu

The Fifth Affiliated Hospital of Guangzhou Medical University.

526136010@qq.com+86 134 1814 0245

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026