relapse, metastatic refractory tumors
Conditions
Interventions
low-dose radiotherapy group:None
Sponsors
Hainan Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. >=18 years of age; 2. Confirmed malignant tumor by cells or pathology; 3. Patients with primary, relapsed or metastatic tumors, or involvement of vital organs, who refuse or cannot tolerate surgery, who fail first-line treatment, who cannot tolerate or refuse systemic treatment; 4. Patients with locally advanced or advanced tumors who have received previous radiotherapy and have difficulty in further radiotherapy; 5. ECOG >=60 points; 6. Expected survival >=3 months; 7. No serious comorbidities (bone marrow, liver and kidney function, coagulation function, heart function) Blood routine: WBC >= 3.0×10^9/L, ANC >= 1.5×10^9/L, PLT >= 90×10^9/L, HGB >= 8g/dL; 1 Liver function: TBIL =55%, QTCF interval 4 weeks; 9. Sign informed consent in writing; 10, consent to collect biological specimens of tissue or blood) for backup;
Exclusion criteria
Exclusion criteria: 1. during pregnancy or lactation; 2. Diffuse metastases of the central nervous system (>=10 brain metastases, meninges, spinal cord); 3. Severe Comorbidities (severe infection, bone marrow suppression, cardiac Cerebrovascular disease, persistent or intractable epilepsy; severe cardiac dysfunction, Coagulation Disorder, active bleeding, electrolyte disorders); 4. KPS <60 points; 5. Any arterial thrombosis, embolism or ischemia occurred within the 6 months before enrollment, such as myocardial infarction, unstable angina, cerebrovascular accident or transient ischemic attack; 6. a history of psychiatric illness, alcoholism, drug use, or drug abuse;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local control rate;Objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of Lymphocytes Subsets with Immunotherapy;Progression-Free-Survival;safety and tolerability;Overall Survival; | — |
Countries
China
Contacts
Public ContactYunxiu Luo
Hainan Cancer Hospital
Outcome results
None listed