Endotracheal intubation
Conditions
Interventions
Experimental group :The initial dose of esketamine was set at 0.5mg/kg. Later, the dose of esketamine was adjusted using the Dixon sequential method based on the response of the previous subject. The
Sponsors
Hainan General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients undergoing elective surgery. 2.Everyone signs an informed consent form. 3.Age 18-59. 4.BMI<30kg/m^2. 5.ASA I or II. 6.Mallampati I or II.
Exclusion criteria
Exclusion criteria: Allergic to the drugs used in the study; Patients with severe respiratory diseases and heart, liver, kidney, brain and functional disorders; Difficult airway or non-disposable tracheal intubation successful;Increased intraocular and intracranial pressure; Patients with bradycardia, tachycardia, hypertension, coronary heart disease, diabetes, etc. Patients with pheochromocytoma; Arrhythmia; Hyperthyroidism and its crisis; Alcohol abuse or addiction or dependence on opioids or hypnotic drugs; People with mental illness; Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of patients who showed positive and negative reactions within 2 minutes after tracheal intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare the changes in hemodynamic parameters of the patients during anesthesia induction and tracheal intubation at time points T0, T1, T2, and T3, etc.;The number of patients who experienced bradycardia, hypotension, choking cough, laryngeal spasm, bronchospasm and other arrhythmias during anesthesia induction and tracheal intubation; | — |
Countries
China
Contacts
Public ContactWu Duozhi
Hainan General Hospital
Outcome results
None listed