constipation in Parkinson's disease
Conditions
Interventions
Control group:vagus nerve stimulation
stimulated group:vagus nerve stimulation
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Diagnosed with PD18 according to the Clinical Diagnostic Criteria for Parkinson's Disease of the Movement Disorder Society, with H&Y staging =24 points.
Exclusion criteria
Exclusion criteria: 1.Use of probiotics or antibiotics within the past 4 weeks; 2.Severe intestinal disorders (such as intestinal obstruction, colitis, etc.) or a history of abdominal surgery Severe intestinal disorders (e.g., intestinal obstruction, colitis, etc.), history of abdominal surgery; 3.Recent use of medications that may affect intestinal function (such as antibiotics, strong painkillers, etc.); 4.Accompanied by severe neurological or psychiatric, renal, cardiovascular, cancer, or hepatic disease; 5.Pregnant women or breastfeeding women; 6.Allergies to electrodes, contraindications; 7.Serious medical conditions that may interfere with the study protocol or confound endpoint assessments: such as uncontrolled hypertension, concomitant diabetes, organ failure, current substance abuse, or inability to provide informed consent; 8.Any other circumstances deemed inappropriate for participation by the researcher; 9.Participation in other concurrent clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of bowel movements; | — |
Secondary
| Measure | Time frame |
|---|---|
| UPDRS;amplitude in EEG;Quality of Life Related to Constipation;Severity of Constipation;Fecal consistency; | — |
Countries
China
Contacts
Public ContactWu Yiwen
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed