Bipolar depressive disorder
Conditions
Interventions
Active stimulation group:Active stimulation
Sponsors
The Second People's Hospital of Guizhou
Eligibility
Sex/Gender
All
Age
13 Years to 28 Years
Inclusion criteria
Inclusion criteria: 1. Age: 13-28 years old, right-handed; 2.Gender: No limit for men and women; 3.Meet DSM-V diagnostic criteria for bipolar disorder, currently in a depressed state (HAMD17>=7 points), and not in a manic or hypomanic state (YMRS<=5 points); 4.The treatment plan for psychiatric drugs is stable within 12 weeks before screening, and the types and dosage of psychiatric drugs used during the planned treatment period do not need to be adjusted (low-dose quetiapine fumarate is used as the basic drug, and the dose is <300mg/day); 5.Junior high school education level and above and sufficient to understand the content of neuropsychological tests.
Exclusion criteria
Exclusion criteria: 1.Intellectual retardation, severe physical disease, equipped with a pacemaker; 2.People with previous diagnosis of mental disorders associated with schizophrenia, schizoaffective mental disorder or other diseases; 3.Those who have abused psychoactive substances within 3 months; 4.Female patients during pregnancy or breastfeeding; 5.Currently (or the last 4 weeks) take more than 2 mg (or equivalent) of lorazepam or any dose of seizure medication every day; 6.Abnormal brain structure or any contraindications for MRI scanning were found through magnetic resonance examination; 7.In the past month, patients receiving MECT-free electroconvulsive (MECT) treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in the Hamilton Depression Rating Scale total score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Response rate; Change from baseline in the Young Mania Rating Scale total score;Change in oxyhemoglobin concentration;Change in functional connectivity strength within or between brain networks; | — |
Countries
China
Contacts
Public ContactShu Yanping
The Second People's Hospital of Guizhou Province
Outcome results
None listed