prolonged disorders of consciousness
Conditions
Interventions
prolonged disorders of consciousness:Synchronized EEG Detection in the Primary Motor Cortex - Paired Association Stimulation Paradigm:
(1) Paired Association Stimulation (PAS): The sequence is central
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 to 80 years old; 2. Coma state caused by brain trauma or stroke for more than 28 days but less than 90 days; 3. Stable vital signs and no acute complications (such as acute pneumonia); 4. Voluntary participation by the patient or their family, with the ability to cooperate with the research process and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. A history of epilepsy or a family history of epilepsy; 2. Conductive, ferromagnetic or other magnetically sensitive metals in the head and neck, or the presence of a pacemaker; 3. Severe complications, including heart failure or renal failure; 4. A history of alcohol dependence, neurological diseases and other complex mental disorders; 5. Use of sedative drugs and drugs that may interfere with brain stimulation, such as baclofen or N-methyl-D-aspartate (NMDA) receptor antagonists, within one week before enrollment and during PAS stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GOS-E (Glasgow Outcome Scale-Extended); | — |
Secondary
| Measure | Time frame |
|---|---|
| CRS-R (Coma Recovery Scale Revised);MEP (Motor evoked potential);PCI (Perturbational Complexity Index);TEPs (TMS-evoked potentials);ERSP (Event-related spectral perturbation);LMFA-AUC (Local mean field amplitude);SCD (Significant current density);SOE (Significant oscillation envelope);SCS (Significant current scattering);SEM(Structural equation model); | — |
Countries
China
Contacts
Public ContactHua Yuan
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed