General Surgery,Gynecological and extracrinal system diseases
Conditions
Interventions
BC group:Saline was given 30 minutes before the end of surgery
EA group:0.125 mg/kg esketamine was given before the end of surgery
EB group:0.25 mg/kg esketamine was given before the end of surgery
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age > 65 and < 90 years; 2. ASA I-III level; 3. Abdominal, gynecological, or urological surgery performed under general anesthesia via laparoscopy or open surgery; 4. Expected anesthesia time exceeding 60 min, and post-operative transfer to PACU; 5. Willing to comply with this experimental process and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Unable to obtain informed consent; 2. Anesthesia time exceeds 4 hours or postoperative transfer to ICU; 3. Known allergy or intolerance to anesthetic drugs or other adverse conditions; 4. Presence of acute or chronic pain preoperatively, peripheral or central nervous system disorders; 5. History of chronic opioid or non-opioid analgesic use; 6. Clearly diagnosed psychiatric history or other neurological or psychiatric conditions affecting judgment with severe cognitive impairment, history of using psychoactive substances; 7. Severe auditory, visual, and speech impairments, inability to speak English or Chinese, communication difficulties; 8. Baseline average arterial pressure (MAP) less than 60 mmHg or greater than 120 mmHg, baseline heart rate less than 45 bpm or greater than 100 bpm, presence of second-degree or higher conduction block; 9. History of severe underlying diseases (untreated or persistent peripheral or central cardiovascular diseases, severe liver and kidney diseases, severe pulmonary diseases).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Awakening time;Incidence of postoperative delirium;Altered sleep rhythms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time;BIS;qCON;qNOX;Use of postoperative analgesic medications;Anxiety level; | — |
Countries
China
Contacts
Public ContactZhao Yuelei
Tianjin Medical University General Hospital
Outcome results
None listed